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. 2016 Oct 27;7(48):79722–79735. doi: 10.18632/oncotarget.12944

Figure 1. Expression of GAC and GLUD1 in TCGA and MLL AML datasets respectively.

Figure 1

A. Principal genes related to Gln metabolism. B. Boxplot comparing expression values of GAC and C. GLUD1 from the TCGA AML dataset. Expression represents batch-effect adjusted, normalized, log2-transformed RPKM (Reads per Kilobase of transcript per Million mapped reads) values. D. GAC and E. GLUD1 expression from the MLL AML dataset in different cytogenetic abnormality categories. The p-values were determined by ANOVA. Asterisk and red boxes denote categories with statistically significant higher GAC expression compared to healthy normal donors; median GAC in normal controls is shown by dotted red line. NK NPM, AML with normal karyotype, NPM-mutant; FLT3-LM NPM, AML with normal karyotype, FLT3-ITD length mutation and NPM-co-mutated; NK, normal karyotype AML.