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. 2016 Oct 28;7(48):79774–79786. doi: 10.18632/oncotarget.12967

Figure 6. Graphic summary of PGCP effects on liver cancer metastasis.

Figure 6

Secreted PGCP triggers liberation of T4 from circulating Tg. T4 is converted to T3 by deiodinase, and T3 promotes DKK4 transcription. DKK4, a Wnt antagonist, is also secreted, and prevents the interaction of LRP6 with Wnt-Frizzled complexes by binding to LRP6. This blocks the canonical Wnt signaling, causing β-catenin degradation via Axin-APC-GSK3β complex. In the absence of PGCP function, the levels of T4, T3 and DKK4 are decreased. This activates the canonical Wnt signaling leading to β-catenin nuclear translocation and induction of metastasis-related target genes thereby promoting metastasis.