Table 2.

The frequency of and odds ratios for subclinical spread relative to anatomic location, recurrent status, and tumor stage.

Appropriate use criteria		Frequency of subclinical spread	Odds ratio [95% CI]	P value
Anatomic location	H or M*	34.2% (175/512)	1.89 [1.07, 3.34]	0.0280
	L**	21.5% (17/79)	1 (ref)
Recurrent status	Recurrent	43.6% (44/101)	1.78 [1.15,1.76]	0.0104
	Primary	30.2% (148/490)	1 (ref)
Tumor stage	In situ	31.6% (143/452)	0.85 [0.57, 1.27]	0.4687
	Invasive	35.3% (49/139)	1 (ref)

^*H or M locations are the head and neck, acral sites, genitalia, and pretibial leg.

^**L locations are all other anatomic sites. ref = reference variable for calculation of odds ratios.