Table 1.
Sterilization methods and processing conditions.
| Sterilization modality |
General classification |
Temperature [°C] |
Relative humidity [%] |
EO conc. [mg L−1] |
|---|---|---|---|---|
| Ethylene Oxide (100% EO) |
Mild | 35 | 35 | 850 |
| Medium | 54 | 50 | 712 | |
| Severe | 54 | 75 | 597 | |
|
Sterilization modality |
General classification |
VHP [mg L1] |
Dwell time [min] |
Total cycle time [h:m:s] |
| Vaporized hydrogen peroxide |
Mild | 1315.9, 2189.6 | 7.5 + 7.5 | 0:47:03 |
| Medium | 1995.2, 2939.4 | 14.0 + 14.0 | 0:48:59 | |
| Severe | 2963.2, 7167.2 | 22.5 + 22.5 | 1:18:05 | |
| Sterilization modality | General classification | Pre-processing equilibration | Delivered dose range [kGy] | |
| Gamma (γ) | Mild | 20 h @ 21 °C | 14.5–16.0 | |
| Medium | 20 h @ 21 °C | 24.0–26.7 | ||
| Severe | 20 h @ 21 °C | 50.0–54.6 | ||
| Electron beam | Mild | 20 h @ 21 °C | 14.0–14.1 | |
| Medium | 20 h @ 21 °C | 24.0–24.7 | ||
| Severe | 20 h @ 21 °C | 49.7–52.3 | ||