Figure 7.

Summary schematic of L1 ORF2p C-terminal region (aa 775–1275). Amino acid scale bar is displayed above. Region identified by Wagstaff et al. (2011) as nonmodular between human and mouse ORF2p is shown in red over ORF2p. Putative RNA binding regions identified by Piskareva et al. (2013) are shown in blue. Amino acids assessed in this manuscript whose mutation had no significant effect on Alu retrotransposition are shown by solid black vertical lines at their approximate location. Y1180, which is important for Alu retrotransposition, is denoted by a dashed black line and a *.