Table 1. Demographic and tumor characteristics of CRC patients according to SMAD4 mutation status.
| Wild-type SMAD4 (n = 644) (%) | Mutated SMAD4 (n = 90) (%) | P | |
|---|---|---|---|
| Sex | 0.020 | ||
| • Female | 286 (44) | 52 (58) | |
| • Male | 358 (56) | 38 (42) | |
| Race/Ethnicity | 0.062* | ||
| • White | 478 (4) | 71 (79) | |
| • Black | 63 (10) | 9 (10) | |
| • Hispanic | 57 (9) | 7 (8) | |
| • Other | 46 (7) | 3 (3) | |
| Age at the time of presentation | 0.320 | ||
| • <65 years | 561 (87) | 75 (83) | |
| • ≥65 years | 83 (13) | 15 (17) | |
| Site of primary tumor | 0.001 | ||
| • Colon | 410 (64) | 75 (83) | |
| • Rectum | 234 (36) | 15 (17) | |
| Disease stage at the time of presentation (available data: n = 691) | 0.260* | ||
| • Stage II | 14 (2) | 0 | |
| • Stage III | 71 (11) | 6 (7) | |
| • Stage IV | 526 (82) | 74 (82) | |
| Presence of distant metastasis (available data: n = 691) | 0.110 | ||
| • Yes | 526 (82) | 74 (82) | |
| • No | 85 (13) | 6 (7) | |
| Tumor grade (available data: n = 534) | 0.828 | ||
| • Well to moderately differentiated | 357 (76) | 50 (79) | |
| • Poorly differentiated | 114 (24) | 13 (20) |
* F-test.