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. 2017 Mar 7;12(3):e0173345. doi: 10.1371/journal.pone.0173345

Table 1. Demographic and tumor characteristics of CRC patients according to SMAD4 mutation status.

Wild-type SMAD4 (n = 644) (%) Mutated SMAD4 (n = 90) (%) P
Sex 0.020
 • Female 286 (44) 52 (58)
 • Male 358 (56) 38 (42)
Race/Ethnicity 0.062*
 • White 478 (4) 71 (79)
 • Black 63 (10) 9 (10)
 • Hispanic 57 (9) 7 (8)
 • Other 46 (7) 3 (3)
Age at the time of presentation 0.320
 • <65 years 561 (87) 75 (83)
 • ≥65 years 83 (13) 15 (17)
Site of primary tumor 0.001
 • Colon 410 (64) 75 (83)
 • Rectum 234 (36) 15 (17)
Disease stage at the time of presentation (available data: n = 691) 0.260*
 • Stage II 14 (2) 0
 • Stage III 71 (11) 6 (7)
 • Stage IV 526 (82) 74 (82)
Presence of distant metastasis (available data: n = 691) 0.110
 • Yes 526 (82) 74 (82)
 • No 85 (13) 6 (7)
Tumor grade (available data: n = 534) 0.828
 • Well to moderately differentiated 357 (76) 50 (79)
 • Poorly differentiated 114 (24) 13 (20)

* F-test.