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. 2017 Mar 7;12(3):e0172749. doi: 10.1371/journal.pone.0172749

Table 4. Results of sensitivity analyses which altered cost-effective intervention.

Dataset Scenario The intervention that is cost-effective for each scenario at £20,000/QALY
All trials Base case TENS
Shortest weekly therapist time used for acupuncture costing Acupuncture
Shortest weekly therapist time used for interferential therapy costing Interferential therapy
Shortened weekly therapist time—75% of benefit in first 30 mins, remainder by 1 hour Interferential therapy
Shortened weekly therapist time—all benefit achieved within 20–30 minutes Interferential therapy
Increase in duration of benefit of all interventions by 6 weeks Interferential therapy
Increase in duration of benefit of acupuncture by 31% Acupuncture
Increase in duration of benefit of interferential therapy by 45% Interferential therapy
Lower 95% CrI from NMA for TENS Acupuncture
Upper 95% CrI from NMA for Acupuncture Acupuncture
Upper 95% CrI from NMA for Braces Braces
Upper 95% CrI from NMA for NMES NMES
Upper 95% CrI from NMA for Static magnets Static magnets
Trials at low risk of selection bias Base case Acupuncture
Shortened weekly therapist time—all benefit achieved within 20–30 minutes Interferential therapy
Lower 95% CrI from NMA for Acupuncture TENS
Upper 95% CrI from NMA for Insoles Insoles
Upper 95% CrI from NMA for Manual therapy Manual therapy
Upper 95% CrI from NMA for Static magnets Static magnets
Upper 95% CrI from NMA for TENS TENS

NMA = network meta-analysis; NMES = neuromuscular electrical stimulation; TENS = transcutaneous electrical nerve stimulation; CrI = credible interval.