Table 1. Variants associated with T1R across geographically separated and ethnically distinct populations.

rsID	M/m	Phase	MAF a	OR (CI 95%) b	p values	I2 (p values)c
rs10826321 (chr10:61,340,203)	A/G	Discovery d	0.26	2.01 (1.49–2.71)	5.1 x 10−06
		Replication	0.27	1.43 (1.15)	0.003
		Validation	0.12	1.36 (1.02)	0.04
		Combined		1.57 (1.33–1.86)	1.4 x 10−07	47.8 (0.15)
rs1875147 (chr10:61,342,450)	T/C	Discovery d	0.31	1.87 (1.42–2.46)	8.4 x 10−06
		Replication	0.31	1.37 (1.11)	0.006
		Validation	0.38	1.47 (1.15)	0.005
		Combined		1.54 (1.32–1.80)	4.5 x 10−08	31.9 (0.23)

The following abbreviations are used: M, Major allele; m, minor allele; MAF, minor allele frequency; OR, odds ratio; CI, Confidence interval.

^a minor allele frequency was estimated in 763 leprosy unaffected parents from both T1R-affecte and T1R-free sets in the discovery phase and T1R-free controls in the confirmation, replication and validation phase.

^b The odds ratio and confidence interval correspond to the minor allele under an additive model. For the replication and validation phase a one-sided test was applied with the risk allele from the discovery phase as reference resulting in a single value lower bond of the confidence interval.

^c The I² statistic describes the percentage of variation across studies followed by p values of the Cochran’s Q-test for heterogeneity.

^d imputed variants INFO = 1.