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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Nature. 2016 Sep 5;539(7627):112–117. doi: 10.1038/nature19796

Extended Data Fig. 4. HIF-2α and HIF-1α levels in sensitive and resistant tumorgrafts.

Extended Data Fig. 4

a, HIF-2α and HIF-1α immunohistochemistry. 786-O cells, which express high levels of HIF-2α, shown as controls. Scale bars, 100 µm. b, Western blot analyses showing heterogeneity within tumors but with overall similar results (compare to Fig. 3c). Green, sensitive; Red, resistant. Asterisks, underloaded samples. c, Heatmap from RNA-seq analysis showing differentially expressed genes in sensitive (S) versus resistant (R) tumourgrafts based on uniform cutoff (see Extended Data Table 3). See Supplementary Fig. 1 for gel source data.