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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Nature. 2016 Sep 5;539(7627):112–117. doi: 10.1038/nature19796

Extended Data Fig. 5. Evaluation of imaging characteristics of tumors in patients corresponding to sensitive, intermediate, and resistant tumorgrafts.

Extended Data Fig. 5

CT scan images from patient tumors that gave rise to tumorgrafts according to TG sensitivity to PT2399. Tumors were classified into masses with peripheral hypervascularity and a central non-enhancing area (blue outline), focally infiltrating (brown outline) and diffuse infiltrating (yellow outline). Three of the seven resistant tumors presented as non-mass-like, infiltrative neoplasms (red arrows) whereas another tumor presented with both a largely necrotic renal mass and retroperitoneal lymph nodes (black outline; white arrows).