Extended Data Table 1. Tumorgraft features.

Fuhrman grade of primary tumor and stage at presentation (metachronous metastasis may have developed); Tissue, engrafted tissue; IHC, immunohistochemistry from tumorgrafts; GI, growth inhibition; ccRCC, clear-cell renal cell carcinoma; tRCC, translocation renal cell carcinoma; Abd, abdominal; Tu Thr, tumor thrombus; LN, lymph node; mut, mutant; wt, wild-type.

Response	XP NO.	Histology	Fuhrman Grade	Tissue	Stage at presentation	VHL status	BAP1 (IHC)	PBRM1 (IHC)	Relative GI% (p value)	RNA seq
Sensitive	XP26	ccRCC	2	Adrenal	pT1aNxMx	mut	mut	wt	87 (0.0003)
	XP144	ccRCC	4	Kidney	pT2aN1Mx	mut	wt	wt	98 (<0.0001)	Y
	XP164	ccRCC*	4	Kidney	pT4NxMx	wt‡	wt	wt	134 (<0.0001)	Y
	XP165	ccRCC	3	Abd wall	pT3bNxMx	mut	wt	mut	112 (<0.0001)
	XP373	ccRCC	4	Tu Thr	pT3aN1M1	wt†	mut	wt	103 (<0.0001)	Y
	XP374	ccRCC*#	4	Kidney	pT4NxMx	mut	wt	wt	109 (<0.0001)	Y
	XP453	ccRCC	3	Tu Thr	pT3bN0Mx	wt†	wt	wt	110 (<0.0001)	Y
	XP454	ccRCC	3	Kidney	pT3aN0Mx	wt‡	mut	wt	156 (0.0032)
	XP469	ccRCC	3	Kidney	pT3bN0Mx	mut	mut	mut	91 (<0.0001)
	XP534	ccRCC	4	Kidney	pT3aN0Mx	mut	mut	n/a	129 (0.0007)
Intermediate	XP237	tRCC	n/a	LN	pT3aN1M1	n/a	wt	wt	43 (0.0144)
	XP391	ccRCC	4	Tu Thr	pT3bN0Mx	mut	wt	mut	45 (0.0018)
	XP426@	ccRCC#	4	Kidney	pT4N1Mx	mut	wt	wt	44 (0.0273)
	XP427@	ccRCC#	4	LN	pT4N1MX	mut	wt	wt	54 (0.0206)
	XP466	ccRCC	3	Kidney	pT3aN0M1	wt	mut	n/a	67 (0.0030)
Resistant	XP169	Unclassified	n/a	Kidney	pT4N1M1	wt	wt	wt	0 (0.0119$)	Y
	XP258	ccRCC*	4	Kidney	pT3aN0M1	mut	mut	wt	39 (0.11)
	XP296	ccRCC*	4	Kidney	pT3aNxM1	mut	wt	wt	29 (0.30)	Y
	XP462	Unclassified	n/a	Kidney	pT3aN0M1	wt	wt	mut	29 (0.11)
	XP490	ccRCC*#	4	Kidney	pT3aN1M1	mut	wt	wt	39 (0.89)	Y
	XP506	ccRCC	3	Ascites	pT3aN1Mx	wt‡	wt	wt	20 (0.76)	Y
	XP530	Unclassified	n/a	Kidney	pT3bN0Mx	wt	n/a	n/a	2 (0.68)

^@Independent tumors from same patient,

^*Sarcomatoid differentiation,

^#Rhabdoid features,

^$PT2399-treated mice had greater relative growth than vehicle-treated mice,

^†promoter methylation,

^‡promoter not methylated