Video 2. shRNA-mediated knockdown of torsinA in the cerebellum of adult mice produces dystonic postures by 13 weeks after injection.
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DOI: 10.7554/eLife.22775.007
A representative video showing the progression of symptoms in a mouse injected with a shRNA against torsinA in the cerebellum at 6 weeks of age. The video starts with the mouse walking in an open-field chamber at three weeks after injection displaying no obvious motor abnormalities. At the 24 s time-point in the video, the same mouse is shown at seven weeks after injection with an unsteady gait and jerky movements. At 1 min 10 s, the same mouse is seen at 13 weeks after injection with exacerbated symptoms including difficulty maintaining balance, frequent repetitive movements and dystonic postures.