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The effect of intranasal IL-1RA administration on IL-1β expression. In the EC group, IL-1β is detected with strong immunoreactivity and largely co-localized with NeuN (A) and Iba-1(B) in the striatum and cortex. However, the IL-1β expression level is remarkably reduced at 6 h after intranasal administration of IL-1RA in the IN group.
