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. 2016 Nov 8;25(2):202–212. doi: 10.4062/biomolther.2016.066

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Copyright ©2017, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 7. — The role of AhR in protection of Rb1 against DOX-induced apoptosis. H9C2 cells were transfected with a control siRNA or a siRNA against AhR, the expression of AhR was determined by RT-PCR and Western blot (A). Transfected cells were treated with DOX in the presence or absence of Rb1 and the mRNA expression of CYP1A1, CYP1A2 and AhR were determined (B). H9C2 cells were pre-treated with vehicle or CH-223191, and then treated with DOX in the presence or absence of Rb1, the mRNA expression of CYP1A1, CYP1A2 and AhR were determined (C). Caspase-3 protein level was determined after AhR knockdown and CH-223191 pre-treatment (D). ^*p<0.05; ^**p<0.01; ^***p<0.001, n.s., not significant.

Fig. 7. — The role of AhR in protection of Rb1 against DOX-induced apoptosis. H9C2 cells were transfected with a control siRNA or a siRNA against AhR, the expression of AhR was determined by RT-PCR and Western blot (A). Transfected cells were treated with DOX in the presence or absence of Rb1 and the mRNA expression of CYP1A1, CYP1A2 and AhR were determined (B). H9C2 cells were pre-treated with vehicle or CH-223191, and then treated with DOX in the presence or absence of Rb1, the mRNA expression of CYP1A1, CYP1A2 and AhR were determined (C). Caspase-3 protein level was determined after AhR knockdown and CH-223191 pre-treatment (D). ^*p<0.05; ^**p<0.01; ^***p<0.001, n.s., not significant.