Table 2. Comparison of Patient Demographics and Tumor Characteristics in the NA+S Group vs the Surgery-Alone Group for the Clinical Node-Negative Patients.
| Characteristic | No. (%) | P Value | ||
|---|---|---|---|---|
| NA+S | Surgery | Overall | ||
| Overall, No. | 195 (28.2) | 496 (71.8) | 691 (100) | |
| Age, mean (SD), y | 61.70 (9.47) | 67.21 (10.54) | 65.65 (10.54) | <.001 |
| Q1-Q3, median (IQR) | 63.00 (56.00-69.00) | 68.00 (60.00-75.00) | 67.00 (58.00-74.00) | |
| Sex | ||||
| Male | 171 (87.7) | 430 (86.7) | 601 (87.0) | .73 |
| Female | 24 (12.3) | 66 (13.3) | 90 (13.0) | |
| Race/ethnicity | ||||
| White | 188 (97.9) | 473 (96.7) | 661 (97.1) | .49 |
| Black | 2 (1.0) | 12 (2.5) | 14 (2.1) | |
| Other | 2 (1.0) | 4 (0.8) | 6 (0.9) | |
| Facility type | ||||
| Community CP | 8 (4.2) | 29 (6.0) | 37 (5.5) | .34 |
| Comprehensive community CP | 81 (42.4) | 179 (37.0) | 260 (38.5) | |
| Academic/research program | 102 (53.4) | 276 (57.0) | 378 (56.0) | |
| Urban/rural | ||||
| Metro | 145 (79.7) | 378 (81.6) | 523 (81.1) | .32 |
| Urban | 34 (18.7) | 70 (15.1) | 104 (16.1) | |
| Rural | 3 (1.6) | 15 (3.2) | 18 (2.8) | |
| Hospital distance, mi | ||||
| Mean (SD) [No.] | 44.25 (104.18) [186] | 52.86 (111.83) [470] | 50.42 (109.71) [656] | .68 |
| Q1-Q3, median (IQR) | 15.85 (6.20-32.70) | 15.55 (5.60-53.10) | 15.60 (5.80-48.90) | |
| Insurance | ||||
| Not insured | 4 (2.1) | 11 (2.3) | 15 (2.2) | .003 |
| Private | 102 (52.3) | 172 (36.4) | 274 (41.0) | |
| Medicaid | 7 (3.6) | 14 (3.0) | 21 (3.1) | |
| Medicare | 81 (41.5) | 275 (58.1) | 356 (53.3) | |
| Other | 1 (0.5) | 1 (0.2) | 2 (0.3) | |
| Income, $ | ||||
| <30 000 | 17 (9.2) | 55 (11.7) | 72 (11.0) | .35 |
| 30 000-34 999 | 27 (14.6) | 87 (18.4) | 114 (17.4) | |
| 35 000-45 999 | 52 (28.1) | 135 (28.6) | 187 (28.5) | |
| >46 000 | 89 (48.1) | 195 (41.3) | 284 (43.2) | |
| Education, % | ||||
| ≥29 | 14 (7.6) | 67 (14.2) | 81 (12.3) | .11 |
| 20-28.9 | 40 (21.6) | 106 (22.5) | 146 (22.2) | |
| 14-19.9 | 58 (31.4) | 129 (27.3) | 187 (28.5) | |
| <14 | 73 (39.5) | 170 (36.0) | 243 (37.0) | |
| Charlson-Deyo Comorbidity Index score | ||||
| 0 | 150 (76.9) | 169 (65.5) | 319 (70.4) | .03 |
| 1 | 36 (18.5) | 70 (27.1) | 106 (23.4) | |
| 2 | 9 (4.6) | 19 (7.4) | 28 (6.2) | |
| Grade | ||||
| I | 5 (3.3) | 40 (8.7) | 45 (7.4) | .15 |
| II | 66 (44.0) | 193 (41.9) | 259 (42.4) | |
| III | 76 (50.7) | 223 (48.4) | 299 (48.9) | |
| IV | 3 (2.0) | 5 (1.1) | 8 (1.3) | |
| Disease site | ||||
| Middle | 9 (4.6) | 55 (11.1) | 64 (9.3) | .008 |
| Lower | 186 (95.4) | 441 (88.9) | 627 (90.7) | |
| Clinical T stage | ||||
| 2 | 51 (26.2) | 326 (65.7) | 377 (54.6) | <.001 |
| 3 | 138 (70.8) | 154 (31.0) | 292 (42.3) | |
| 4 | 6 (3.1) | 16 (3.2) | 22 (3.2) | |
| Tumor size, mm | ||||
| Mean (SD) [No.] | 46.65 (72.12) [124] | 37.49 (27.48) [407] | 39.63 (42.43) [531] | .06 |
| Q1-Q3, median (IQR) | 38.00 (25.00-50.00) | 32.00 (23.00-45.00) | 34.00 (23.00-(50.00) | |
| Inpatient stay, d | ||||
| Mean (SD) [No.] | 12.19 (8.81) [161] | 17.74 (17.1) [226] | 15.43 (14.56) [387] | <.001 |
| Q1-Q3, median (IQR) | 10.00 (8.00-15.00) | 12.00 (9.00-21.00) | 11.00 (8.00-18.00) | |
| Margins | ||||
| Negative | 174 (91.1) | 407 (89.5) | 581 (89.9) | .53 |
| Positive | 17 (8.9) | 48 (10.5) | 65 (10.1) | |
| Path T stage | ||||
| 0 | 17 (13.9) | 17 (3.1) | <.001 | |
| 1 | 19 (15.6) | 84 (19.6) | 103 (18.7) | |
| 2 | 29 (23.8) | 148 (34.5) | 177 (32.1) | |
| 3 | 49 (40.2) | 176 (41.0) | 225 (40.8) | |
| 4 | 5 (4.1) | 14 (3.3) | 19 (3.4) | |
| IS | 3 (2.5) | 7 (1.6) | 10 (1.8) | |
| Path N stage | ||||
| 0 | 92 (70.8) | 312 (75.5) | 404 (74.4) | .28 |
| 1 | 38 (29.2) | 101 (24.5) | 139 (25.6) | |
| No. of nodes examined | ||||
| Mean (SD) [No.] | 9.14 (10.50) [189] | 10.63 (9.60) [484] | 10.21 (9.88) [673] | .03 |
| Q1-Q3, median (IQR) | 7.00 (2.00-13.00) | 8.50 (3.00-15.00) | 8.00 (3.00-15.00) | |
| No. of positive nodes | ||||
| Mean (SD) [No.] | 0.83 (2.56) [161] | 1.02 (2.59) [424] | 0.97 (2.58) [585] | .39 |
| Q1-Q3, median (IQR) | 0.00 (0.00-0.00) | 0.00 (0.00-1.00) | 0.00 (0.00-1.00) | |
| Readmission | ||||
| None | 171 (95.5) | 227 (91.9) | 398 (93.4) | .32 |
| Planned | 2 (1.1) | 4 (1.6) | 6 (1.4) | |
| Unplanned | 6 (3.4) | 16 (6.5) | 22 (5.2) | |
| 30-d Mortality | ||||
| No | 189 (96.9) | 464 (93.5) | 653 (94.5) | .08 |
| Yes | 6 (3.1) | 32 (6.5) | 38 (5.5) | |
Abbreviations: CP, cancer program; IQR, interquartile range;
NA+S, neoadjuvant chemoradiation plus surgery; Q, quintile.