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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Genet Epidemiol. 2016 Dec 26;41(3):244–250. doi: 10.1002/gepi.22023

Figure 1.

Figure 1

Distributions of the maximum 4 degree-of-freedom likelihood ratio test statistics, across all pairwise SNP-SNP interactions, for 1,000 permutation case-parent trio data sets of European ancestry. (A) The maximum test statistic across all SNP-SNP interactions in all 78 region pairs. The largest observed test statistic (LRT=40.25) is indicated by the red vertical line. (B) The maximum test statistic across all SNP-SNP interactions in the IRF6 / MAFB pair. (C) The maximum test statistic across all SNP-SNP interactions in all region pairs except the IRF6 / MAFB pair. The largest observed test statistic (LRT=32.17) is indicated by the blue vertical line.