Skip to main content
. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Bone Miner Res. 2016 Oct 28;32(3):461–472. doi: 10.1002/jbmr.3005

Fig. 1.

Fig. 1

Expression of mRNA and miRNA in synovium in STA. (A) Average clinical scores over a time course in STA. Values are the mean ±SD. RNA was collected from pooled synovial tissue at day 0 (nonarthritic, D0: n =10 mice/pool, 2 pools), day 10 (D10: n =3 mice/pool, 2 pools), and day 21 (D21: n =8 mice/pool, 2 pools). Genes previously found to be regulated are indicated. (B, C) miRNA-mRNA integrated analysis at peak inflammation. Predicted target genes of regulated miRNAs at D10 compared with nonarthritic synovium were found to correlate with regulated mRNAs (≥1.5 fold). (D) Significantly enriched pathways for upregulated genes (p ≤0.001). Genes in the overlapped regions in B were subjected to ontology analysis. (E) Significantly enriched pathways for downregulated genes. Genes in the overlapped regions in C were subjected to ontology analysis.