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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: J Immunol. 2017 Feb 3;198(6):2426–2433. doi: 10.4049/jimmunol.1601048

Figure 1. NLRP12 expression is increased after combined injury, and acts to limits mortality and weight loss.

Figure 1

Wildtype C57BL/6 mice were subjected to sham, 5Gy of γ-irradiation, a 20% total body surface area burn or a combined injury (RCI). (A) mRNA was isolated from spleen, bone marrow, and whole lung at 3, 7, and 14 days post injury. Relative Nlrp12 - expression was determined by qRT-PCR. (n=6/timepoint). Wildtype C57BL/6 or Nlrp12−/− mice were subjected to sham, 5Gy of γ-irradiation, a 20% total body surface area burn or RCI. (B) Survival and (C) weight loss were quantified. Data represented as mean ± SEM, with statistical significance compared to sham defined as *, p<0.05, **, p<0.005 and ***, p<0.001 by Student’s t test, with experiments performed in triplicate.