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. 2017 Feb 15;9(2):214–229.

Figure 10.

Figure 10

Cellular dysfunction signaling in renal tubules by day 60 after CRS induction. A-F: Illustrating microscopic finding (200 ×) of immunohistochemical (IHC) staining of β-catenin+ cells to distribute mainly in renal tubules. G: Analytical results of number of β-catenin+ cells, * vs. other groups with different symbols (†, ‡, §, ¶, #), p<0.0001. H-M: Illustrating microscopic findings (200 ×) IHC staining of Wnt4+ cells mainly in renal tubules. N: Analytical results of number of Wnt4+ cells, * vs. other groups with different symbols (†, ‡, §, ¶, #), P<0.0001. Scale bars in right lower corner represent 50 µm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 8 for each group). Symbols (*, †, ‡, §, ¶, #) indicate significance (at 0.05 level). SC = sham control; CKD = chronic kidney disease; CRS = cardiorenal syndrome; Mel = melatonin; Ex4 = exendin-4.