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. 2017 Feb 15;9(2):247–260.

Figure 1.

Figure 1

MG (i.c.v.) induced performance deficits (Morris water maze task). A. Mean escape latency decreased with increased training. Latency was significantly longer after MG (0.35, 0.7 or 1.4 µmol) than after NS (P<0.05). B. No differences in swimming speed were observed among the five groups. C. In the spatial probe trial, mice spent significantly less time in the target quadrant after MG (0.35, 0.7 or 1.4 µmol) than after NS (P<0.05). D. Mice made significantly fewer crossings of the target location after MG (0.35, 0.7 or 1.4 µmol) than after NS (P<0.05). The difference in effect between the three concentrations of MG was not significant (P>0.05). n = 7-10 mice per group. *P<0.05 vs. NS group; **P<0.01 vs. NS group. Aβ, amyloid beta (positive control); MG, methylglyoxal; NS, normal saline (negative control).