Figure 2.

Effect of WIN55,212-2 (1 µM) on 3-NP (1 mM)-induced mitochondrial dysfunction (MTT reduction) and lipid peroxidation (TBARS levels) in rat brain synaptosomal/mitochondrial-enriched fractions. Synaptosomal fractions were pre-incubated with WIN55,212-2 and further incubated with 3-NP for 60 min. Data are expressed as mean values ± S.E.M. of n=6-8 experiments per group. Symbols denote statistical differences vs. control (^aP<0.05) and against 3-NP (^bP<0.05). Two-way ANOVA followed by Bonferroni’s test.