Figure 5.

Effect of WIN55,212-2 on the 3-NP-induced alterations in locomotor activity in rats. Animals received WIN55,212-2 (1 mg/kg, i.p. once a day × 6 days prior to 3-NP) or vehicle, plus 3-NP (500 nmol/µL, intrastriatal bilateral dose) and challenged 6 days after intrastriatally lesioned in an open field device. In the upper left panel, the horizontal activity is presented; in the upper right panel, the time spent in the center of the device is shown; in the panel at the bottom, the resting time is depicted. Mean values ± S.E.M of n=5 rats per group are shown; ^*P<0.05, different of Sham; ^#P<0.05, different of 3-NP group. Two-way ANOVA followed by Bonferroni’s test.