Figure 6.

Effect of WIN55,212-2 on 3-NP-induced morphological alterations in the rat striatum. Animals received WIN55,212-2 (1 mg/kg, i.p. once a day ×6 days prior to 3-NP) or vehicle, plus 3-NP (500 nmol/µL, intrastriatal bilateral dose) and striata were histologically processed and stained with Hematoxylin & Eosin. In the left upper panel, the four micrographs of striatal tissue from rats of all treatments are shown at the 10× magnification. In the right upper panel, micrographs of the striatal from all treatments are presented at 40×. ^*Represent normal cells; +Denote pyknotic cells. In the bottom, counting of cell damage per field is depicted. Mean values ± S.E.M of n=5 rats per group are shown; ^*P<0.05, different of Sham; ^#P<0.05, different of 3-NP group. Two-way ANOVA followed by Bonferroni’s test.