Figure 6.

bFGF exerts long-term protective effects on brain structures after neonatal HI injury. Rats were treated with bFGF twice a day for 7 d after HI, and their brains were obtained at 1 week post-HI. A. Representative brain images of the sham rats, HI rats and HI rats treated with bFGF. B. Representative images of immunohistochemical staining for MAP-2 and MBP. C. Quantification of ipsilateral MAP-2 area loss. ^*represents P<0.01 versus the sham group, and ^#represents P<0.05 versus the HI group. D. Quantification of ipsilateral MBP area loss. ^*represents P<0.01 versus the sham group, and ^#represents P<0.05 versus the HI group. Area loss was measured as 1-(ipsi-/contralateral MAP-2-positive or MBP-positive area). All data represent the mean value ± SEM, n=4.