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MiR-21 directly targets the 3’-UTR of LRP6. (A) Putative binding site of miR-21 in the 3’-UTR of LRP6 mRNA. HepG2 cells were transfected with 25 nM miR-21 mimic or control mimic. Cellular RNA or total protein was isolated at 48 h post-transfection for qRT-PCR (B) or western blot (C) analysis. **P < 0.01 represents the relative mRNA levels in the miR-21 mimic group compared with that in the mock transfected group.
