Fig. 1.

Invasive non-keratinizing squamous cell carcinoma of the laryngeal ventricular fold. a Large islands of tumor cells with well-defined borders on the right and central side, on the left bottom side, more infiltrative growth pattern is present. b The same part of the tumor showing strong and diffuse p16 immunostaining, both nuclear and cytoplasmic. c The same part of the tumor; cancer cells show positive in situ hybridization for E6/E7 mRNA for high-risk HPV with numerous dot-like signals highlighting the viral infection