Table 1.

Conditions with chronic ACTH excess in man.

Normal adrenal cortexa
ACTH/Cortrosyn administration to normal volunteers
ACTH-dependent Cushing’s syndrome
Cushing’s disease; ectopic ACTH secretion syndrome
General resistance to glucocorticoids
Abnormal adrenal cortex: disorders of steroid synthesisb
Congenital adrenal hyperplasia
21 Hydroxylase-, 11 hydroxylase-, 17 hydroxylase deficiencies
Inhibitors of adrenal steroidogenesis
Metyrapone, ketoconazole, etomidate, aminoglutethimide, LCI699
Abnormal adrenal cortex: «missing» adrenal glands
Acquired destruction
Addison’s disease
Bilateral adrenalectomy
Adrenolytic drugs (o,p′DDD)
Congenital developmental defects

^aModel to study both the functional and anatomical effects of chronic ACTH excess.

^bModel to study the anatomical effects of chronic ACTH excess.