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. 2016 Sep 26;36(9):1211–1222. doi: 10.1038/onc.2016.284

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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PDX recapitulate stromal properties of human tumor microenvironment. (a) Representative views of smooth-muscle actin (SMA), CXCR4 and CXCL12 immunostaining (IHC) in PDX models derived from Luminal A (LumA, Left), HER2 (Middle) and Triple-Negative (TN, Right) breast cancers (BC). Scale bar: 125 μm (low magnification) and 30 μm (high magnification in inserted sections). (b–d) Bar graphs comparing histological scores (HScores, see methods) of stromal SMA (b), epithelial CXCR4 (c) and stromal CXCL12 staining (d) from LumA, HER2 and TN PDX, as indicated. Data are shown as means±s.e.m (N=15 PDX, including five Lum, three HER2 and seven TN). P-values are based on Mann–Whitney test. (e) Positive correlation between SMA and CXCL12 stromal HScores, established from tumors of all BC subtypes (LumA, HER2 and TN). Correlation coefficient and P-value are based on Spearman's test.