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. 2017 Mar 7;23(9):1568–1575. doi: 10.3748/wjg.v23.i9.1568

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Upregulated microRNAs after DNA methyltransferases knockdown (A); and Methylation and expression changes of hsa-miR-183 after DNA methyltransferases knockdown (B). A: Cluster analysis after single and combined DNMT knockdown using siRNAs (as indicated in the lower panel) shows upregulation of selected microRNAs (right panel). High, intermediate, and low microRNA expression levels in the heatmap are indicated with red, black, and green, respectively. B: Upon DNMT1 knockdown in HLE cell lines, DNA methylation at the promoter of miR-183 decreased significantly (right panel, P = 0.0015) accompanied by elevated miR-183 expression (left panel, P = 0.04). NC = negative control siRNA and DNMT (1, 3A, 3B) = DNA methyl transferase 1, -3A, -3B siRNA treated samples. DNMT: DNA methyltransferase.