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. 2017 Mar;18:67–80. doi: 10.1016/j.epidem.2017.01.002

Table 2.

Parameter values and assumptions that are similar across all models.

Parameters Value* Source Reported range Source
Human parameters
Average duration of symptomatic untreated stage (days) District and year specific (See SF2) CARE data N/A N/A
Average duration treatment 1 (days) 28 CARE data N/A N/A
Average duration treatment 2 (days) 28 CARE data N/A N/A
Average duration of putatively recovered stage (months)** 21 (Ramesh et al., 2015, Uranw et al., 2011, Rahman et al., 2010) 21–36 (Ramesh et al., 2015)
Average duration of PKDL (years)** 5 Expert opinion and (Ramesh et al., 2015) 0.5–5 (Ramesh et al., 2015, Islam et al., 2013)
Excess mortality rate among untreated symptomatic cases (per day) 1/150 Assumption
Excess mortality rate among treated symptomatic cases (per day) 1/120 Assumption
Fraction of failed first-line treatments District-specific
(See SF2)
CARE data N/A N/A
Fraction of putatively recovered cases that develop PKDL 2.5% CARE data 2.4%–17% (Uranw et al., 2011, Islam et al., 2013)
Infectivity of symptomatic untreated cases 1 Reference value 0.02–0.42 (Quinnell and Courtenay, 2009)
Relative infectivity of patients under treatment 1 and 2 0.5 Expert opinion Unknown



Sandfly parameters
Average life expectancy of the sandfly (days) 14 (Palit et al., 2011) 10–20
Average duration of incubation period in sandflies (days)** 5 (Sacks and Perkins, 1985) 4.7–5.1 (Hurwitz et al., 2011, Hati et al., 1984, Shortt, 1945)
Sandfly biting rate (per day)** 1/4 (Anon., 2016, Hati et al., 1984) 1/5–1/4 (Anon., 2016, Hurwitz et al., 2011, Hati et al., 1984, Palit et al., 2011)
Probability of transmission from an infected sandfly to susceptible human 1 Reference value N/A
*

Parameter values held fixed in model fitting and predictions unless otherwise stated.

**

Ranges given are for average (median) duration based on the literature. Durations treated as exponentially distributed in models.