Table 2.
Parameters | Value* | Source | Reported range | Source |
---|---|---|---|---|
Human parameters | ||||
Average duration of symptomatic untreated stage (days) | District and year specific (See SF2) | CARE data | N/A | N/A |
Average duration treatment 1 (days) | 28 | CARE data | N/A | N/A |
Average duration treatment 2 (days) | 28 | CARE data | N/A | N/A |
Average duration of putatively recovered stage (months)** | 21 | (Ramesh et al., 2015, Uranw et al., 2011, Rahman et al., 2010) | 21–36 | (Ramesh et al., 2015) |
Average duration of PKDL (years)** | 5 | Expert opinion and (Ramesh et al., 2015) | 0.5–5 | (Ramesh et al., 2015, Islam et al., 2013) |
Excess mortality rate among untreated symptomatic cases (per day) | 1/150 | Assumption | ||
Excess mortality rate among treated symptomatic cases (per day) | 1/120 | Assumption | ||
Fraction of failed first-line treatments | District-specific (See SF2) |
CARE data | N/A | N/A |
Fraction of putatively recovered cases that develop PKDL | 2.5% | CARE data | 2.4%–17% | (Uranw et al., 2011, Islam et al., 2013) |
Infectivity of symptomatic untreated cases | 1 | Reference value | 0.02–0.42 | (Quinnell and Courtenay, 2009) |
Relative infectivity of patients under treatment 1 and 2 | 0.5 | Expert opinion | Unknown | |
Sandfly parameters | ||||
Average life expectancy of the sandfly (days) | 14 | (Palit et al., 2011) | 10–20 | |
Average duration of incubation period in sandflies (days)** | 5 | (Sacks and Perkins, 1985) | 4.7–5.1 | (Hurwitz et al., 2011, Hati et al., 1984, Shortt, 1945) |
Sandfly biting rate (per day)** | 1/4 | (Anon., 2016, Hati et al., 1984) | 1/5–1/4 | (Anon., 2016, Hurwitz et al., 2011, Hati et al., 1984, Palit et al., 2011) |
Probability of transmission from an infected sandfly to susceptible human | 1 | Reference value | N/A |
Parameter values held fixed in model fitting and predictions unless otherwise stated.
Ranges given are for average (median) duration based on the literature. Durations treated as exponentially distributed in models.