Table 1.
Model comparison.
Model structure | ICL model | CWRU model |
---|---|---|
Simulation framework | Deterministic-probabilistic | Deterministic-probabilistic |
Implementation language | R | Mathematica/Python |
Age-related exposure to infection | Relative exposure estimated from age-stratified infection intensity data | Baseline test data provides relevant SAC parameters, the other (untested) younger/older age groups are estimated via community dynamic simulations (Y1-Y3) |
Distribution of individual predisposition to heavy or light infection | No individual-level propensity | Age-specific biological (in-host) parameters: worm fecundity, egg-release aggregation |
Age-related contribution to the reservoir of infection in the environment | Assumed to be identical to exposure to infection | Age-specific exposure/contamination, and the resulting human-snail transmission coefficients |
Distribution of contributions to reservoir of infection among individuals | No individual-level contributions | No individual contribution, but age-specific contributions |
Acquired immunity to infection | Assume no acquired immunity | Assume no acquired immunity |
Coverage and compliance | Structured by age group | Structured by age group |
Demographic data source | Data collected in SCORE project | Data collected in SCORE project |
Reproductive model | Mating function for dioecious monogamous parasite | Mating count for dioecious monogamous parasite, with age-specific fecundity and crowding. Low cut-off worm burden for mating success |