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. 2017 Jan 4;117(3):1200–1214. doi: 10.1152/jn.00836.2016

Fig. 6.

Fig. 6.

Effect of S2 stimulation on discharge of rostroventromedial medullary (RVM) neurons in animals with neuropathic hypersensitivity. A: heat-evoked limb withdrawal latency before, during, and 2 min following the end of contralateral S2 stimulation determined concurrently when performing recordings of RVM neurons. B: heat-evoked change in discharge rates of ON-cells before (Pre) or 2 min after (Post) the end of real or fake stimulation of the right S2. C: latency to the heat-evoked discharge inhibition (OFF-cells) or burst discharge (ON-cells) before and after real or fake S2 stimulation. D: duration of the heat-evoked discharge inhibition (OFF-cells) or burst discharge (ON-cells) before and after real or fake S2 stimulation. E: heat-evoked change in the late discharge rate (left) or burst discharge duration (right) of ON-cells “during” S2 stimulation (immediately after offset of S2 stimulus). F: heat-evoked change in the late discharge rate (left) or the duration of discharge inhibition (right) of OFF-cells “during” S2 stimulation (immediately after offset of S2 stimulus). In B, 0 Hz (broken horizontal line) represents the corresponding baseline discharge rate and values <0 Hz represent heat-evoked decreases in the rate, while values >0 Hz represent heat-evoked increases in the rate. In E and F, 0 represents the corresponding Pre-S2 value, and values <0 represent decreases induced by S2 stimulation, real S2 = 30 µA, fake S2 = 0 µA. In all graphs, bars show the mean values and the error bars represent SD (in A, n = 8; in B–D, nOFF = 17, nONrealS2 = 24, nONfakeS2 = 16; in E, nreal = 21, nfake = 19; in F, nreal = 7). *P < 0.05, ***P < 0.005 (in A–D, Bonferroni-corrected t-test; in E, paired t-test).