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. 2017 Apr;23(4):567–577. doi: 10.1261/rna.060236.116

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© 2017 Friesen et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 5. — Clitocine alters near-cognate tRNA decoding of nonsense codons. (A) Graph showing that clitocine induces a 9.2-fold increase in luciferase enzyme activity (y-axis) over that in DMSO treated (control) 293H cells stably expressing LUC-_(UGA20)-SF. Error bars represent standard deviation of the mean for at least two determinations. (B) Graph showing a change in the ratio of first to third codon position mispairing during near-cognate tRNA decoding of the UGA nonsense codon. Error bars represent the standard deviation of the mean for three determinations. Data are from Table 1.