Table 1.

Characteristics of the eligible studies evaluating high miRNA expression levels in tissue samples and patient survival data.

Study (year) (ref)	Country	Cancer	Stage	Test	Cut-off value	miRNA	Sample size	MFD	Newcastle-Ottawa Quality Assessment Scale
									Selection	Compatibility	Outcome
Feng et al. (2015) [13]	China	HCC	NA	qRT-PCR/ISH	ROC	200a	115	120 m	★★	★	★★
Li et al. (2015) [17]	China	HCC	I–IV	qRT-PCR/ISH	NA	429	161	96 m	★★★★	★	★★★
Lu et al. (2015) [8]	China	GC	I–IV	qRT-PCR	Median	141	141	60 m	★★★	★	★★
Wang et al. (2015) [14]	China	Glioma	I–IV	qRT-PCR	NA	200b	123	5 y	★★★	★★	★★
Yao et al. (2015) [9]	China	BC	I–III	qRT-PCR	Comparison w/normal group	200b	278	10 y	★★★★	★	★★
Zhao et al. (2015) [18]†	China	NSCLC	IIB-IIIB	qRT-PCR	Median	200c	78	40 m	★★★	★	★★
Cao et al. (2014) [19]	China	OC	I–IV	qRT-PCR	Median	200a/b/c	100	56 m	★★★★	★	★★★
Diaz et al. (2014) [20]	Spain	CRC	II	qRT-PCR	Maxstat R package	429	127	120 m	★★★	★★	★★
Kim et al. (2014) [21]	Korea	NSCLC	I–IV	qRT-PCR	Median	200c	72	125 m	★★★	★★	★★★
Li et al. (2014) [22]†	China	NSCLC	IIIB-IV	qRT-PCR	Minimum P value	200c	150	18.5 [9.6] m	★★★	★★	★★★
Liu et al. (2014) [23]	China	HCC	I–IV	ISH	Median	141	212	100 m	★★★	★	★★
Song et al. (2014) [24]∗	China	GC	I–IV	qRT-PCR	Median/Lowest quintile values	200a/b/c	373	112 m	★★★	★	★★
Tejero et al. (2014) [25]	Spain	NSCLC	I–III	qRT-PCR	Maxstat R package	141/200c	155	160 m	★★★	★★	★★★
Zhang et al. (2014) [26]∗	China	AST	III-IV	qRT-PCR	Median	200b	122	120 m	★★★★	★★	★★★
Zhu et al. (2014) [11]	China	PC	I–IV	qRT-PCR	Mean	141	94	200 m	★★★★	★	★★
Zhu et al. (2014) [15]	China	NSCLC	I–IV	qRT-PCR	ROC	429	70	30 m	★★	★	★★
Berghmans et al. (2013) [16]	Europe	NSCLC	IV (79%)	qRT-PCR	predicted score	200c	38	60 m	★★★	★★	★★
Huang et al. (2013) [27]	China	HCC	I-II	qRT-PCR	Mean	429	138	140 m	★★★	★	★★★
Li et al. (2013) [28]	China	CRC	I–III	qRT-PCR	Median	429	107	82 m	★★★★	★	★★★
Tang et al. (2013) [29]	China	GC	I–IV	ISH	Median	200b/c	126	NA	★★★	★	★★
Torres et al. (2013) [10]†	Europe	EEC	I–IV	qRT-PCR	Median/ROC	200c/429 [429]	30	150 m	★★★★	★	★★
Xiao et al. (2013) [30]	China	HCC	I–III	qRT-PCR	Mean	200a	120	60 m	★★★	★	★★★
Zhao at al. (2013) [12]	China	PC	I–IV	qRT-PCR	Median	141	40	50 m	★★	★	★★
Leskelä et al. (2011) [31]∗	Spain	OC	I–IV	qRT-PCR	Median	429 [141, 200a/b/c, 429]	72	128 m	★★	★	★★
Marchini et al. (2011) [32]∗	Italy	OC	I	qRT-PCR	Contal & O'Quigley method	200b/c (A)	89	240 m	★★	★	★★
						200c (B)	55
Yu et al. (2010) [33]	Japan	PC	I–IV	qRT-PCR	Median	200c	99	101 m	★★★	★	★★★

[Value] indicates the microRNA type or maximum follow-up duration for progression-free survival.

MFD: maximal follow-up duration, AST: astrocytoma, BC: breast cancer, CRC: colorectal cancer, EEC: endometrioid endometrial carcinoma, EOC: epithelial ovarian cancer, ESC: esophageal squamous cancer, GC: gastric cancer, HCC: hepatocellular carcinoma, OC: ovarian cancer, PC: pancreatic cancer, PrC: castration-resistant prostate cancer, NSCLC: non-small-cell lung cancer, ROC, receiver operating characteristic analysis, NA: not available, mo: months, wk: weeks, and y: years.

^∗Study reporting both overall survival and progression-free survival data.

^†Study reporting only progression-free survival data.