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. 2017 Feb 28;18(9):2113–2123. doi: 10.1016/j.celrep.2017.02.014

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© 2017 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Ultrastructural Analysis of ZIKV-Infected hNPCs

(A–H) TEM images of 70-nm-thin sections of ZIKV-infected and resin-embedded hNPCs. Cells were mock infected (A and B) or infected (MOI = 5) with the H/PF/2013 (C and D) or MR766 (E–H) ZIKV strain for 24 hr. Yellow boxed areas are enlarged in the given panels. Overviews of ZIKV-infected cells (C and E) revealing incised nuclei and the ER inclusion. Mitochondria (mito) are located in the cell periphery adjacent to the outer rim of the ER (C and E). Virus-induced vesicles (Ve) and virions (Vi) are indicated in the magnified panels (D and H) and are marked with white and gold arrowheads, respectively. Red arrowheads, cytoskeletal filaments. Scale bars, 2 μm in (A), (C), and (E); 500 nm in (F) and (G); 200 nm in (B), (D), and (H).