Role of DHT- and EST-regulated proteins in energy metabolism. The figure illustrates a simplification of several processes related to energy metabolism and mitochondrial compartment. Proteins that appeared to be up-regulated by DHT (orange), or both DHT and EST (blue) are also represented. GAD-3P, glyceraldehyde-3-phosphate; FFA, free fatty acids; HBP, hexosamine biosynthetic pathway; Gln, glutamine; Glu, glutamate; ROS, reactive oxygen species; α-KG, alpha-ketoglutarate; OAA, oxaloacetate.