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Model for two-pronged IgG-FcRn binding mechanism. Step 1: High affinity interaction of IgG CH2/CH3 domains and FcRn, step 2: Fab-FcRn interaction for briakinumab. The structural model shows the IgG HC (dark gray), LC (light gray), FcRn α-chain (green) and β2-microglobulin (yellow).
