Table II. List of proteins with significantly different NPX values between Prostasomes and Milk exosomes.

Protein symbol	Average NXP milk exosomes	Average NPX prostasomes	log2FCa	FDR
Enriched in milk exosomes
CXCL5	0.94	7.61	−6.67	<0.001
SOD1	1.09	6.20	−5.11	<0.001
PRSS8	4.02	8.04	−4.03	<0.001
EPHA2	0.24	3.95	−3.71	<0.001
MIA	0.17	3.29	−3.12	<0.001
FR-alpha	4.59	7.49	−2.89	<0.001
MET	0.67	3.56	−2.89	<0.001
CD69	1.09	3.97	−2.88	0.002
PDGF subunit B	2.67	5.46	−2.79	<0.001
CCL19	0.43	3.20	−2.77	<0.001
KLK6	0.17	2.87	−2.70	0.002
HS1	2.20	4.28	−2.08	0.002
Enriched in prostatasomes
GDF-15	9.39	2.73	6.67	<0.001
NKX31	6.72	0.42	6.30	<0.001
SRC	5.40	0.42	4.98	<0.001
hK11	6.38	2.07	4.31	<0.001
HE4	5.87	1.67	4.21	0.001
CDKN1B	4.38	0.42	3.95	<0.001
ErbB3/HER3	6.34	2.86	3.48	<0.001
TNFRSF10B	5.53	2.06	3.48	<0.001
PlGF	6.59	3.22	3.36	0.009
Flt3L	3.66	0.42	3.23	<0.001
TRAIL-R2	4.82	1.90	2.92	0.001
eIF-4B	3.33	0.42	2.90	<0.001
FUR	4.84	2.07	2.77	<0.001
IGF1R	4.63	1.89	2.75	<0.001
PLAU	6.51	3.95	2.55	0.009
EIF4EBP1	3.26	0.89	2.37	0.001
BR	2.77	0.42	2.34	<0.001
EIF4B	2.71	0.42	2.29	<0.001
HB-EGF	2.50	0.42	2.07	0.002

^a log2 fold changes for the comparison between prostasomes versus milk exosomes. Proteins were considered significantly enriched when log2FC > 2 and FDR < 0.01.