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. 2017 Mar 8;7:44126. doi: 10.1038/srep44126

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Copyright © 2017, The Author(s)

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A bootstrap value of 1000 runs was used to calculate the distance using MEGA 6 software. AaOKS1, Aloe arborescens octaketide synthase 1; AaPCS, A. arborescens pentaketide chromone synthase; AbDpgA, Amycolatopsis balhimycina dihydroxyphenylacetic acid synthase; AhSTS, Arachis hypogaea stilbene synthase; AmQNS, Aegle marmelos quinolone synthase; AtCHS, Arabidopsis thaliana chalcone synthase; BsNCHS, Bacillus subtilis naringenin-chalcone synthase; CsCHS, Cannabis sativa chalcone synthase; CmACS, Citrus microcarpa acridone synthase; CmQNS, C. microcarpa quinolone synthase; CsPKSIIIB, C. sinensis polyketide synthase type III B; ClCHS, Curcuma longa chalcone synthase; ClDCS, C. longa diketide CoA synthase; ClCURS1, C. longa curcumin synthase 1; EcFABH, Escherichia coli K-12 beta-ketoacyl-ACP synthase III; Gh2PS, Gerbera hybrida 2-pyrone synthase; GhCHS1, G. hybrida naringenin-chalcone synthase 1; GmBPS, Garcinia mangostana benzophenone synthase; HaBPS, Hypericum androsaemum benzophenone synthase; HpOKS, H. perforatum octaketide synthase; HpPKS, H. perforatum polyketide synthase; HmSTS, Hydrangea macrophylla stilbenecarboxylate synthase; HsPKS1, Huperzia serrata chalcone synthase-like polyketide synthase 1; MpSTCS, Marchantia polymorpha stilbenecarboxylate synthase 2; MsCHS2, Medicago sativa chalcone synthase 2; MtPKS1, Mycobacterium tuberculosis phenolpthiocerol synthesis type-I polyketide synthase; NcPKS, Neurospora crassa type III pentaketide synthase; OsCHS1, Oryza sativa chalcone synthase 1; OsCUS, O. sativa curcuminoid synthase; PaPQSD, Pseudomonas aeruginosa 2-heptyl-4(1 H)-quinolone synthase; PaPQSH, P. aeruginosa 2-heptyl-3-hydroxy-4(1 H)-quinolone synthase; PBBS, Phalaenopsis sp. bibenzyl synthase; PiPKS, Plumbago indica polyketide synthase; PnVPS, Psilotum nudum valerophenone synthase; PpPKS1, Physcomitrella patens 2′-oxoalkylresorcinol synthase; PsCHS, Pisum sativum chalcone synthase; PsCHS, Pinus strobus chalcone synthase; PsSBS, P. strobus stilbene synthase; RgACS2, Ruta graveolens acridone synthase 2; RgCHS1, R. graveolens chalcone synthase 1; RpALS, Rheum palmatum aloesone synthase; RpBAS, R. palmatum benzalacetone synthase; SaBIS, Sorbus aucuparia biphenyl synthase; SbARS1, Sorghum bicolor alkylresorcinol synthase 1; SbARS2, S. bicolor alkylresorcinol synthase 2; ScTHNS, Streptomyces coelicolor 1,3,6,8-tetrahydroxynaphthalene synthase; SgTHNS, Streptomyces griseus 1,3,6,8-tetrahydroxynaphthalene synthase; VvTHS1, Vitis vinifera resveratrol synthase 1; ZmCHS2, Zea mays chalcone synthase 2. Accession numbers of protein sequences used in this figure are given in Supplementary Information.