Figure 6. Crystal structure of MGS0169.

(a) Overall structure of the MGS0169 protomer (several orientations related by 90° rotation). The ribbon diagram of the core domain is colored gray (helices) and cyan (β-strands). (b) Three views of the MGS0169 tetramer related by 90° rotation with monomers colored gray, cyan, green, and orange. The last view is also shown in a surface presentation to demonstrate the tight packing of monomers. (c) Close-up view of the MGS0159 active site showing the bound unknown ligand (UL). The amino acid side chains and ligand molecule are shown as sticks along a protein ribbon colored gray. In the MGS0169 structure, the second protomer (colored wheat) contributes to the substrate binding site of the first protomer (shown in gray).