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. 2017 Mar 8;7:43567. doi: 10.1038/srep43567

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Copyright © 2017, The Author(s)

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(a) Representative pictures show the macroscopic metastatic nodules (indicated by arrows) on the liver surface 7 days after the mice were injected intrasplenically with LV12 cells transfected with Amigo2 or control siRNA. Scale bar: 10 mm. (b) H&E staining of the liver metastatic foci. Scale bar: 500 μm. (c) Representative bioluminescent images of livers 7 days after intrasplenic injection of QRsP-11-Luc or LV12-Luc cells transfected with either Amigo2 or control siRNA are shown. (d) Metastatic nodules on the liver surface in individual mice were counted. Bar graphs show means ± SD from two independent experiments with similar results. QRsP-11 and untreated LV12 cells, n = 12; control siRNA or Amigo2 siRNA-transfected LV12 cells, n = 11. (e) The number of metastatic foci per mm² of liver area was determined. Bar graphs show means ± SD from two independent experiments with similar results. QRsP-11 and untreated LV12 cells, n = 12; control siRNA or Amigo2 siRNA-transfected LV12 cells, n = 11. (f) Quantification of total flux (photons per sec) from the livers shown in Fig. 4c. Bar graphs show means ± SD (n = 9 in each group).