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. Author manuscript; available in PMC: 2017 Mar 8.
Published in final edited form as: Conf Proc IEEE Eng Med Biol Soc. 2015;2015:6514–6518. doi: 10.1109/EMBC.2015.7319885

Fig. 4.

Fig. 4

The Impact of somatic mutations in the upstream regulatory subnetwork of PTEN on its gene expression inconsistency. Depth penalization parameter is set to α = ½. The bars show the relative degree of association of mutations in genes (horizontal-axis) on the level of inconsistency between the observed PTEN gene expression level and its predicted value. The impact is divided between protein truncating mutations (blue) and other missense mutations (yellow) normalized by their counts in the respective genes.