Table 1.
Demographics of the study population
| Total (n = 422) |
Invasive ventilation (n = 131) | Noninvasive ventilation (n = 150) |
Spontaneous ventilation (n = 141) |
p | |
|---|---|---|---|---|---|
| Gestational age (weeks) median (IQR) |
34.0 (31.0–37.0) | 31.0 (27.0–36.0) |
33.0 (31.0–35.0) |
35.0 (34.0–38.0) |
<.0001 |
| Gestational age (weeks) | <.0001 | ||||
| 24–29 N (%) | 86 (20.4) | 59 (45.0) | 25 (16.7) | 2 (1.4) | |
| 30–32 N (%) | 76 (18.0) | 19 (14.5) | 45 (30.0) | 12 (8.5) | |
| 33–36 N (%) | 150 (35.6) | 22 (16.8) | 57 (38.0) | 71 (50.4) | |
| 37–42 N (%) | 110 (26.1) | 31 (23.7) | 23 (15.3) | 56 (39.7) | |
| Gestational age (weeks) ≤32 N (%) |
162 (38.4) | 78 (59.5) | 70 (46.7) | 14 (9.9) | < .0001 |
| Birth weight (g) median (IQR) |
1921 (1368–2739) |
1600 (896–2550) |
1878 (1367–2430) |
2295 (1835–3130) |
<.0001 |
| Sex male N (%) |
226 (53.6) | 82 (62.6) | 77 (51.3) | 67 (47.5) | 0.0356 |
| Born in same hospital as NICU, n (%) | 345 (81.8) | 93 (71.0) | 133 (88.7) | 119 (84.4) | 0.0004 |
| Type of delivery Caesarean, n(%) |
300 (71.1) | 96 (73.3) | 119 (79.3) | 85 (60.3) | 0.0013 |
| Age at admission (h) median (IQR) |
0.4 (0–3.3) | 0.5 (0–3.2) | 0.2 (0–0.6) | 0.5 (0–19.1) | 0.0017 |
| CRIB score median (IQR) |
0 (0–1) | 2 (1–5) | 0 (0–1) | 0 (0–1) | <.0001 |
| APGAR score at 5 min Median (IQR) |
9 (8–10) | 7 (6–9) | 8 (8–9) | 10 (9–10) | <.0001 |
| Intubated on admission, n (%) | 79 (18.7) | 79 (60.3) | NA | NA | NA |
| Duration of IV (hours) median (IQR) |
NA | 71.7 (16.8–157.0) |
NA | NA | NA |
| Duration of NIV (hours) median (IQR) |
NA |
N = 101 120 (33.0–262.8) |
N = 150 36.1 (16.9–113.2) |
NA | NA |
| Status at discharge Dead, n (%) |
14 (3.3) | 12 (9.2) | 1 (0.7) | 1 (0.7) | <.0001 |
| Days of participation in trial median (IQR) |
15 (7–28) | 28 (13–28) | 17 (8–28) | 9 (5–15) | 0.0001 |
| Days of hospitalization median (IQR) |
15 (7–28) | 25 (13–47) | 17.0 (8–28) | 8.5 (5–15) | <.0001 |
Values were missing for some variables. NA Not applicable, CRIB Clinical Risk Index for Babies, IV invasive ventilation, NIV noninvasive ventilation, SV spontaneous ventilation