Figure 1.

PPARγ agonists increase [¹²⁵I]‐Aβ_1‐40 efflux and LRP1 expression at the BBB in db/db mice. [¹²⁵I]‐Aβ_1‐40 and [¹⁴C]‐inulin were injected simultaneously, the percentage of [¹²⁵I]‐Aβ1‐40 BBB clearance (A) and the levels of [¹²⁵I]‐Aβ_1‐40 in the brain (B) and plasma (C) were determined by γ counting after 30 min. (D) Representative immunohistochemical microphotographs of LRP1, (E) analysis for % of LRP1‐positive vessels (arrow, brain microvessels positive LRP1), (F) representative immunoblot detected by Western blot, (G) protein quantification, (H) LRP1 mRNA expression and (I) mRNA quantification of expressed as a percentage of the db/m are shown. Original magnification is 200×. Values shown are expressed as mean ± SEM; n = 3–4. *P < 0.05, **P < 0.01 versus db/db + Veh group.