Figure 2.

(A) Concentration‐dependent kinetics of adenosine‐mediated change in the FRET ratio. The recordings were expressed as % of the maximal response achieved with 1 mM adenosine, reproduced from Hoffmann et al., 2005. (B) Relationship between the adenosine concentration and k_obs, the apparent rate constant of the change in the FRET ratio, reproduced from Hoffmann et al., 2005. (C) Concentration–response effects of ACh on the FRET response of the M3‐ACh‐receptor sensor, reproduced from Ziegler et al., 2011. (D) Differential effects of partial agonists in different receptor domains as observed for the α2a‐adrenoceptor, reproduced from Zürn et al., 2009.