Figure 1.

BoNT/A and sumatriptan effects on bilateral allodynia induced by unilateral TMJ inflammation. BoNT/A (5 U kg⁻¹) was injected into the TMJ (5 U kg⁻¹ i.a.) or trigeminal ganglion (2 U kg⁻¹ i.g.) 3 days before CFA. Facial allodynia was measured with von Frey filaments 24 h after CFA injection into the TMJ. Sumatriptan (175 mg kg⁻¹) was administered p.o. 24 h after CFA, and allodynia was measured 2 h after sumatriptan. Scatter plot represents data of individual animals, and horizontal lines and bars indicate mean ± SEM. n (animals per group) = 5–9. *P < 0.05, ** P < 0.01, ***P < 0.001, significantly different from saline control; ⁺⁺⁺ P < 0.001, significantly different from saline + CFA; one‐way ANOVA followed by Newman–Keuls post hoc test.