Figure 3.
Neurogenic plasma protein extravasation in dura is reduced by i.a./i.g. BoNT/A and p.o. sumatriptan – photographs of open cranial cavities. Left side: TMJ was injected with CFA 1 day before animal perfusion with saline. BoNT/A was injected into the TMJ (5 U kg−1 i.a.) or trigeminal ganglion (2 U kg−1 i.g.) 3 days before CFA. Sumatriptan (175 mg kg−1) was administered p.o. 24 h after CFA. Four days following BoNT/A or 2 h after sumatriptan rats were intravenously injected with Evans blue (40 mg kg−1) and perfused with saline. Photographs were taken upon the perfusion with saline and the removal of brain tissue.