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Effect of Compound 9a on MKP‐1 association with MAPK and acetylation during sepsis. Mice were injected i.p. with vehicle or 10 mg∙kg−1 Compound 9a 2 h before and immediately after CLP. Association of MKP‐1 with MAPK (A) and with Ac‐K and HDAC (B) were measured. The results are presented as mean ± SEM of six mice per group. Liver tissue was collected 3 h after CLP. * P < 0.05, significantly different from sham. † P < 0.05, significantly different from CLP.
