Figure 2.

The mGlu₅ PAM decreases cue‐induced reinstatement the following day. (A) Rats learned to self‐administer cocaine in the presence of a light CS, such that responding on the active lever increased across days. (B) Responding on the active lever decreased over repeated lever extinction sessions. In both (A) and (B), responding is collapsed across groups. (C) Systemic injection of CDPPB decreased responding at CS‐induced reinstatement carried out drug‐free 24 h later (*drug × lever interaction, P < 0.05). Final group sizes: Handle vehicle: n = 7, Handle MTEP: n = 7, CS extinction vehicle: n = 8, CS extinction MTEP: n = 8.