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. 2016 Feb 17;173(6):1005–1017. doi: 10.1111/bph.13404

Figure 1.

Figure 1

Concentration–response curves to BK in the absence (A, control) or presence of L‐NAME (B, NOS inhibitor), Indo + L‐NAME (C, inhibitors of COX and NOS) and Indo + L‐NAME + TRAM34 + apamin (D, inhibitors of COX, NOS, KCa3.1 and KCa2.x channels) in endothelium‐intact mesenteric arteries of rats treated with placebo, 48 h or 72 h of continuous i.v. infusion of serelaxin. Mesenteric artery sensitivity (E, pEC50) to BK in placebo, 48 or 72 h after continuous i.v. infusion of serelaxin. Concentration–response curves to SNP (F) in endothelium‐intact mesenteric arteries of rats treated with placebo, 48 h or 72 h of continuous i.v. infusion of serelaxin. n = 7–11 per group. * P < 0.05; pEC50 significantly different from placebo; one‐way anova, Dunnett's post hoc test.